Added: Mara Krogman - Date: 17.10.2021 12:09 - Views: 23818 - Clicks: 2366
To determine the local effects of cigarette smoke on the pulmonary vasculature, we measured pulmonary artery pressure—flow curves in isolated, blood-perfused pig lungs before and after 4 exposures to cigarette smoke.
During hypoxia inspired P O 250 mmHgwhen baseline vasomotor tone was high, cigarette smoke caused an acute transient vasodilation. During control inspired P O 2mmHgwhen baseline tone was low, no ificant effect was observed. In addition to this acute effect, cigarette smoke caused a depression of the pulmonary pressor response to hypoxia, which developed gradually during the course of the experiment. Indomethacin did, however, prevent the gradual depression of the pulmonary vasoconstrictor response to hypoxia. If you have purchased access to this content or have a subscription to this content, please log in using the link below.
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